Combined dipeptidyl peptidase-4 inhibitor with low-dose testosterone exerts greater efficacy than monotherapy on improving brain function in orchiectomized obese rats

• Main Authors: Puntarik Keawtep, Wasana Pratchayasakul, Apiwan Arinno, Nattayaporn Apaijai, Titikorn Chunchai, Sasiwan Kerdphoo, Thidarat Jaiwongkum, Nipon Chattipakorn, Siriporn C. Chattipakorn
• 格式: 雜誌
• 出版: 2019
• 主題: Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066281284&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65354
• 機構: Chiang Mai University

© 2019 Elsevier Inc. Both obesity and orchiectomy lead to the development of brain pathologies and cognitive decline. Testosterone replacement therapy (2 mg/kg/day TRT)and dipeptidyl peptidase-4 inhibitor (vildagliptin)improved cognition in orchiectomized rats, and obese rats. However, both had no b...