Discovery of potential sclerostin inhibitors from plants with loop2 region of sclerostin inhibition by interacting with residues outside Pro-Asn-Ala-Ile-Gly motif

• Main Authors: Wipawadee Yooin, Chalermpong Saenjum, Jetsada Ruangsuriya, Supat Jiranusornkul
• Format: Journal
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063954610&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65402
• Institution: Chiang Mai University

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Sclerostin, an antagonist of the Wnt/β-catenin signaling pathway, was discovered as a potential therapeutic target for stimulating bone formation in osteoporosis. In this study, molecular docking was employed to predict the...