Novel Electrochemical Flow Injection Procedure for Albendazole Determination using Boron-doped Diamond thin Film Electrode
© 2019, Pleiades Publishing, Ltd. Abstract: The homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer c...
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| Main Authors: | , , , , |
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| Format: | Journal |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066501076&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/65486 |
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| Institution: | Chiang Mai University |
| Summary: | © 2019, Pleiades Publishing, Ltd. Abstract: The homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer containing 20% (v/v) methanol at pH 2.5. Using the BDD electrode well-defined and highly reproducible cyclic voltammogram was obtained with current signal-to-background ratio of higher than those obtained from the glassy carbon electrode. Flow injection analysis system with amperometric detection using the homemade thin-layer electrochemical flow-through cell with BDD electrode was studied. The hydrodynamic voltammogram of the drug exhibited single well defined maximum oxidation peak at 0.95 V versus Ag/AgCl. A low detection limit of 2 ppm was obtained. The current–concentration relationship was rectilinear over the concentration range of 3.3‒150 ppm. The proposed method was applied to albendazole tablets with satisfactory results. |
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