Novel Electrochemical Flow Injection Procedure for Albendazole Determination using Boron-doped Diamond thin Film Electrode

• Main Authors: Watthanachaiyapong Janhom, Narabhats Rannurags, Arunee Kongsakphaisal, Wasan Sirisungworwong, Saisunee Liawruangrath
• Format: Journal
• Published: 2019
• Subjects: Chemistry
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066501076&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65486
• Institution: Chiang Mai University

© 2019, Pleiades Publishing, Ltd. Abstract: The homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer containing 20% (v/v) methanol at pH 2.5. Using the BDD electrode well-defined and highly reproducible cyclic voltammogram was obtained with current signal-to-background ratio of higher than those obtained from the glassy carbon electrode. Flow injection analysis system with amperometric detection using the homemade thin-layer electrochemical flow-through cell with BDD electrode was studied. The hydrodynamic voltammogram of the drug exhibited single well defined maximum oxidation peak at 0.95 V versus Ag/AgCl. A low detection limit of 2 ppm was obtained. The current–concentration relationship was rectilinear over the concentration range of 3.3‒150 ppm. The proposed method was applied to albendazole tablets with satisfactory results.