Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition

• Main Authors: Panupong Mahalapbutr, Nitchakan Darai, Wanwisa Panman, Aunchan Opasmahakul, Nawee Kungwan, Supot Hannongbua, Thanyada Rungrotmongkol
• Format: Journal
• Published: 2019
• Subjects: Multidisciplinary
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069434452&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65901
• Institution: Chiang Mai University

© 2019, The Author(s). The human T1R2-T1R3 sweet taste receptor (STR) plays an important role in recognizing various low-molecular-weight sweet-tasting sugars and proteins, resulting in the release of intracellular heterotrimeric G protein that in turn leads to the sweet taste perception. Xylitol an...