Analysis of chorismate mutase catalysis by QM/MM modelling of enzyme-catalysed and uncatalysed reactions

• Main Authors: Claeyssens F., Ranaghan K.E., Lawan N., MacRae S.J., Manby F.R., Harvey J.N., Mulholland A.J.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79951592576&partnerID=40&md5=2fbf0f31ca5e28cc4081c2cdb4a656b3; http://cmuir.cmu.ac.th/handle/6653943832/6602
• Institution: Chiang Mai University

Chorismate mutase is at the centre of current controversy about fundamental features of biological catalysts. Some recent studies have proposed that catalysis in this enzyme does not involve transition state (TS) stabilization but instead is due largely to the formation of a reactive conformation of...