One-pot Three Components Synthesis of 3-(α-arylaminobenzylidene)indoles Catalysed by L-proline
The one-pot three-components synthesis of 3-(α-arylaminobenzyl)indoles is achieved from indole, aromatic aldehydes and anilines by using L-proline as a catalyst. The reaction produced 3-alkyl-indoles in dominance over the bisindolyl alkanes. The reported L-proline catalyzed synthetic methodology is...
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| Main Authors: | , , |
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| Language: | English |
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Science Faculty of Chiang Mai University
2019
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| Subjects: | |
| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=6242 http://cmuir.cmu.ac.th/jspui/handle/6653943832/66154 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | The one-pot three-components synthesis of 3-(α-arylaminobenzyl)indoles is achieved from indole, aromatic aldehydes and anilines by using L-proline as a catalyst. The reaction produced 3-alkyl-indoles in dominance over the bisindolyl alkanes. The reported L-proline catalyzed synthetic methodology is an environmentally benign alternative for the synthesis of 3-alkyl-indoles with comparable catalytic efficiency to that of costly and toxic metal based catalysts. |
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