Strong fluctuations in DNA Unzipping
In a living cell two strands of nucleotides forming a double helix are unbound, in response to enzymatic force, to the independent strands. Such force-induced structural transformation of DNA is studied in the context of phase transition. Fluctuations around a double helix, which is the ground-state...
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| Language: | English |
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Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=6253 http://cmuir.cmu.ac.th/jspui/handle/6653943832/66170 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | In a living cell two strands of nucleotides forming a double helix are unbound, in response to enzymatic force, to the independent strands. Such force-induced structural transformation of DNA is studied in the context of phase transition. Fluctuations around a double helix, which is the ground-state energy configuration, are so strong that the mean field description is no longer valid. Treating two strands of nucleotides as the one dimensional continuous entities interacting via a potential, the growth of the helix wavevector under recursion relations, derived by the momentum shell renormalization group, accounts for the rapidly spatial variation of two unbound strands. |
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