Biological Activitiesof Integric Acid Isolated from the Wood-Decay Fungus Xylaria feejeensis 2FB-PPM08M
Integric acid was isolated from the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M grown on potato dextrose broth. The compound showed weak antimicrobial activity against Gram-positive bacteria. However, it was inactive against M. tuberculosis and had no antiviral effects on HSV-1 and H5N1 v...
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| Main Authors: | , , , , |
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| Language: | English |
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Science Faculty of Chiang Mai University
2019
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| Subjects: | |
| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=5524 http://cmuir.cmu.ac.th/jspui/handle/6653943832/66827 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | Integric acid was isolated from the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M grown on potato dextrose broth. The compound showed weak antimicrobial activity against Gram-positive bacteria. However, it was inactive against M. tuberculosis and had no antiviral effects on HSV-1 and H5N1 viruses. Notably, the metabolite exhibited inhibitory activity against the malarial parasite Plasmodium falciparum K1 strain, with IC50 values of 6.91 µM, and non-cytotoxicity against African green monkey kidney fibroblasts (Vero cells). This is the first report on its activity against P. falciparum. |
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