Biological Activitiesof Integric Acid Isolated from the Wood-Decay Fungus Xylaria feejeensis 2FB-PPM08M

• Main Authors: Totsaporn Srisapoomi", Tsuyoshi Ichiyanagi, Hiromitsu Nakajima, Tadanori Aimi, Sophon Boonlue
• Language: English
• Published: Science Faculty of Chiang Mai University 2019
• Subjects: Biological activities; Integric acid; Wood-decay fungus; Xylaria feejeensis
• Online Access: http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=5524; http://cmuir.cmu.ac.th/jspui/handle/6653943832/66827
• Institution: Chiang Mai University

Integric acid was isolated from the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M grown on potato dextrose broth. The compound showed weak antimicrobial activity against Gram-positive bacteria. However, it was inactive against M. tuberculosis and had no antiviral effects on HSV-1 and H5N1 viruses. Notably, the metabolite exhibited inhibitory activity against the malarial parasite Plasmodium falciparum K1 strain, with IC50 values of 6.91 µM, and non-cytotoxicity against African green monkey kidney fibroblasts (Vero cells). This is the first report on its activity against P. falciparum.