Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhi...

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Main Authors:	Choommongkol R., Jongkol R., Prabpai S., Kongsaeree P., Meepowpan P.
Format:	Article
Language:	English
Published:	2014
Online Access:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84860307253&partnerID=40&md5=514b8ff225a777e81d8328f6ceb56e40 http://cmuir.cmu.ac.th/handle/6653943832/6706
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Institution:	Chiang Mai University
Language:	English

id	th-cmuir.6653943832-6706
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spelling	th-cmuir.6653943832-67062014-08-30T03:51:08Z Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps Choommongkol R. Jongkol R. Prabpai S. Kongsaeree P. Meepowpan P. Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC 50 values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved. 2014-08-30T03:51:08Z 2014-08-30T03:51:08Z 2012 Article 9574166 10.1016/j.tetasy.2012.03.006 TASYE http://www.scopus.com/inward/record.url?eid=2-s2.0-84860307253&partnerID=40&md5=514b8ff225a777e81d8328f6ceb56e40 http://cmuir.cmu.ac.th/handle/6653943832/6706 English
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
language	English
description	Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC 50 values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved.
format	Article
author	Choommongkol R. Jongkol R. Prabpai S. Kongsaeree P. Meepowpan P.
spellingShingle	Choommongkol R. Jongkol R. Prabpai S. Kongsaeree P. Meepowpan P. Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
author_facet	Choommongkol R. Jongkol R. Prabpai S. Kongsaeree P. Meepowpan P.
author_sort	Choommongkol R.
title	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_short	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_full	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_fullStr	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_full_unstemmed	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_sort	synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem michael addition-dieckmann condensation reactions as the key steps
publishDate	2014
url	http://www.scopus.com/inward/record.url?eid=2-s2.0-84860307253&partnerID=40&md5=514b8ff225a777e81d8328f6ceb56e40 http://cmuir.cmu.ac.th/handle/6653943832/6706
_version_	1681420663966924800

Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

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