Anti-human CD63 monoclonal antibody COS3A upregulates monocyte-induced IL-10 excretion leading to diminution of CD3-mediated T cell response

• Main Authors: Siriwan Wansook, Kodchakorn Mahasongkram, Nuttaphol Chruekamlow, Supansa Pata, Watchara Kasinrerk, Panida Khunkaewla
• Format: Journal
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072214951&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/67612
• Institution: Chiang Mai University

© 2019 Elsevier Ltd Human CD63 has been reported to play a role either as an inhibitor or as a co-stimulator of T- cell responses, although the mechanism of this is unclear. In this study, an anti-human CD63 monoclonal antibody (mAb) COS3A was used to monitor the role of CD63 in T-cell activation. M...