Combined iron chelator with N-acetylcysteine exerts the greatest effect on improving cardiac calcium homeostasis in iron-overloaded thalassemic mice

• Main Authors: Natticha Sumneang, Sirinart Kumfu, Juthamas Khamseekaew, Natthaphat Siri-Angkul, Suthat Fucharoen, Siriporn C. Chattipakorn, Nipon Chattipakorn
• Format: Journal
• Published: 2020
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072649582&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/68046
• Institution: Chiang Mai University

© 2019 Elsevier B.V. The morbidity and mortality in thalassemia patients are predominantly caused by iron overload cardiomyopathy (IOC). Iron-induced cardiac intracellular Ca2+ ([Ca2+]i) dysregulation is among the core pathophysiological processes in IOC-related heart failure. Although cardioprotect...