Global Retinoblastoma Presentation and Analysis by National Income Level

• Main Authors: Ido Didi Fabian, Elhassan Abdallah, Shehu U. Abdullahi, Rula A. Abdulqader, Sahadatou Adamou Boubacar, Dupe S. Ademola-Popoola, Adedayo Adio, Armin R. Afshar, Priyanka Aggarwal, Ada E. Aghaji, Alia Ahmad, Marliyanti N.R. Akib, Lamis Al Harby, Mouroge H. Al Ani, Aygun Alakbarova, Silvia Alarcón Portabella, Safaa A.F. Al-Badri, Ana Patricia A. Alcasabas, Saad A. Al-Dahmash, Amanda Alejos, Ernesto Alemany-Rubio, Amadou I. Alfa Bio, Yvania Alfonso Carreras, Christiane Al-Haddad, Hamoud H.Y. Al-Hussaini, Amany M. Ali, Donjeta B. Alia, Mazin F. Al-Jadiry, Usama Al-Jumaly, Hind M. Alkatan, Charlotta All-Eriksson, Ali A.R.M. Al-Mafrachi, Argentino A. Almeida, Khalifa M. Alsawidi, Athar A.S.M. Al-Shaheen, Entissar H. Al-Shammary, Primawita O. Amiruddin, Romanzo Antonino, Nicholas J. Astbury, Hatice T. Atalay, La Ongsri Atchaneeyasakul, Rose Atsiaya, Taweevat Attaseth, Than H. Aung, Silvia Ayala, Baglan Baizakova, Julia Balaguer, Ruhengiz Balayeva, Walentyna Balwierz, Honorio Barranco, Covadonga Bascaran, Maja Beck Popovic, Raquel Benavides, Sarra Benmiloud, Nissrine Bennani Guebessi, Rokia C. Berete, Jesse L. Berry, Anirban Bhaduri, Sunil Bhat, Shelley J. Biddulph, Eva M. Biewald, Nadia Bobrova, Marianna Boehme, H. C. Boldt, Maria Teresa B.C. Bonanomi, Norbert Bornfeld, Gabrielle C. Bouda, Hédi Bouguila, Amaria Boumedane, Rachel C. Brennan, Bénédicte G. Brichard, Jassada Buaboonnam, Patricia Calderón-Sotelo, Doris A. Calle Jara, Jayne E. Camuglia, Miriam R. Cano, Michael Capra, Nathalie Cassoux, Guilherme Castela, Luis Castillo, Jaume Català-Mora, Guillermo L. Chantada, Shabana Chaudhry, Sonal S. Chaugule, Argudit Chauhan, Bhavna Chawla, Violeta S. Chernodrinska, Faraja S. Chiwanga, Tsengelmaa Chuluunbat, Krzysztof Cieslik, Ruellyn L. Cockcroft, Codruta Comsa, Zelia M. Correa, Maria G. Correa Llano, Timothy W. Corson, Kristin E. Cowan-Lyn, Monika Csóka, Xuehao Cui, Isac V. Da Gama, Wantanee Dangboon
• Format: Journal
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081545321&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/68276
• Institution: Chiang Mai University

© 2020 Cambridge University Press. All rights reserved. Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- A nd middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs.