Gemcitabine enhances cytotoxic activity of effector T-lymphocytes against chemo-resistant cholangiocarcinoma cells

• Main Authors: Nunghathai Sawasdee, Chutamas Thepmalee, Jatuporn Sujjitjoon, Petlada Yongpitakwattana, Mutita Junking, Naravat Poungvarin, Pa thai Yenchitsomanus, Aussara Panya
• Format: Journal
• Published: 2020
• Subjects: Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076520956&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/68436
• Institution: Chiang Mai University

© 2019 Elsevier B.V. Cholangiocarcinoma (CCA) can resist chemotherapy resulting in treatment failure. Gemcitabine, a chemotherapeutic drug, can sensitize cancer cells to become susceptible to cytotoxic T-lymphocytes (CTLs). We, therefore, hypothesized that a combination of gemcitabine and CTLs would...