An alternative synthesis of (+) - propranolol and (+) atenolol
Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai,...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84867869116&partnerID=40&md5=7078d7887a3e89fe60d336742d9852e9 http://cmuir.cmu.ac.th/handle/6653943832/6932 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai, Chiang Mai, 50290 Thailand. |
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