An alternative synthesis of (+) - propranolol and (+) atenolol
Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai,...
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th-cmuir.6653943832-69322014-08-30T03:51:24Z An alternative synthesis of (+) - propranolol and (+) atenolol Inkum R. Teerawutgulrag A. Puangsombat P. Rakariyatham N. Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai, Chiang Mai, 50290 Thailand. 2014-08-30T03:51:24Z 2014-08-30T03:51:24Z 2012 Article 19057873 http://www.scopus.com/inward/record.url?eid=2-s2.0-84867869116&partnerID=40&md5=7078d7887a3e89fe60d336742d9852e9 http://cmuir.cmu.ac.th/handle/6653943832/6932 English |
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Thailand |
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| language |
English |
| description |
Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. © 2012 by Maejo University, San Sai, Chiang Mai, 50290 Thailand. |
| format |
Article |
| author |
Inkum R. Teerawutgulrag A. Puangsombat P. Rakariyatham N. |
| spellingShingle |
Inkum R. Teerawutgulrag A. Puangsombat P. Rakariyatham N. An alternative synthesis of (+) - propranolol and (+) atenolol |
| author_facet |
Inkum R. Teerawutgulrag A. Puangsombat P. Rakariyatham N. |
| author_sort |
Inkum R. |
| title |
An alternative synthesis of (+) - propranolol and (+) atenolol |
| title_short |
An alternative synthesis of (+) - propranolol and (+) atenolol |
| title_full |
An alternative synthesis of (+) - propranolol and (+) atenolol |
| title_fullStr |
An alternative synthesis of (+) - propranolol and (+) atenolol |
| title_full_unstemmed |
An alternative synthesis of (+) - propranolol and (+) atenolol |
| title_sort |
alternative synthesis of (+) - propranolol and (+) atenolol |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84867869116&partnerID=40&md5=7078d7887a3e89fe60d336742d9852e9 http://cmuir.cmu.ac.th/handle/6653943832/6932 |
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1681420706372386816 |