Biological effects of curcumin-loaded PLGA nanoparticle conjugated with anti-p-glycoprotein antibody on multidrug resistant cancer cells in vitro and in animal models

• Main Author: Wanisa Punfa
• Other Authors: Pornngarm Dejkriengkraikul
• Format: Theses and Dissertations
• Language: English
• Published: เชียงใหม่ : บัณฑิตวิทยาลัย มหาวิทยาลัยเชียงใหม่ 2020
• Subjects: Biological effects; Curcumin-loaded; Nanoparticle conjugated
• Online Access: http://cmuir.cmu.ac.th/jspui/handle/6653943832/69409
• Institution: Chiang Mai University

Curcumin (Cur), a phenolic compound purified from the rhizome of Curcuma longa, has been reported to reduce both expression and function of P-glycoprotein (P-gp), a drug efflux pump. However, low level of oral bioavailability, poor absorption ability, a high metabolic rate, poor pharmacokinetics and...