Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus

• Main Authors: Thanika Promchai, Pawinee Janhom, Wisanu Maneerat, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Stephen G. Pyne, Thunwadee Limtharakul
• Format: Journal
• Published: 2020
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059066859&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70041
• Institution: Chiang Mai University

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.