Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor exerts greater efficacy than atorvastatin on improvement of brain function and cognition in obese rats

• Main Authors: Busarin Arunsak, Wasana Pratchayasakul, Patchareeya Amput, Kenneth Chattipakorn, Theetouch Tosukhowong, Sasiwan Kerdphoo, Thidarat Jaiwongkum, Chanisa Thonusin, Siripong Palee, Nipon Chattipakorn, Siriporn C. Chattipakorn
• Format: Journal
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087205764&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70188
• Institution: Chiang Mai University

© 2020 Elsevier Inc. The accumulation of lipid as a result of long-term consumption of a high-fat diet (HFD) may lead to metabolic and brain dysfunction. Atorvastatin, a recommended first-line lipid-lowering agent, has shown beneficial effects on metabolic and brain functions in several models. Rece...