Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves

Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves

Copyright © 2020 Elsevier Ltd. All rights reserved. The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from...

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Bibliographic Details
Main Authors: Songyot Anuchapreeda, Riki Anzawa, Natsima Viriyaadhammaa, Waranya Neimkhum, Wantida Chaiyana, Siriporn Okonogi, Toyonobu Usuki
Format: Journal
Published: 2020
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086355236&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70205
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Institution: Chiang Mai University
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Summary:Copyright © 2020 Elsevier Ltd. All rights reserved. The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from a hexane fractional extract and identified as agrostophillinol. This is the first report of agrostophillinol isolated from kaffir lime leaves. In terms of cytotoxicity, agrostophillinol exhibited IC50 values of 36.27 ± 7.30 and 53.44 ± 10.63 μg/mL against EoL-1 and HL60 cells, respectively. Agrostophillinol also exhibited potent anti-inflammatory activity, significantly inhibiting IL-6 secretion.

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