Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves

Copyright © 2020 Elsevier Ltd. All rights reserved. The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from...

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Main Authors:	Songyot Anuchapreeda, Riki Anzawa, Natsima Viriyaadhammaa, Waranya Neimkhum, Wantida Chaiyana, Siriporn Okonogi, Toyonobu Usuki
Format:	Journal
Published:	2020
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086355236&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70205
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-702052020-10-14T08:47:11Z Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Copyright © 2020 Elsevier Ltd. All rights reserved. The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from a hexane fractional extract and identified as agrostophillinol. This is the first report of agrostophillinol isolated from kaffir lime leaves. In terms of cytotoxicity, agrostophillinol exhibited IC50 values of 36.27 ± 7.30 and 53.44 ± 10.63 μg/mL against EoL-1 and HL60 cells, respectively. Agrostophillinol also exhibited potent anti-inflammatory activity, significantly inhibiting IL-6 secretion. 2020-10-14T08:25:36Z 2020-10-14T08:25:36Z 2020-07-15 Journal 14643405 2-s2.0-85086355236 10.1016/j.bmcl.2020.127256 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086355236&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70205
institution	Chiang Mai University
building	Chiang Mai University Library
continent	Asia
country	Thailand Thailand
content_provider	Chiang Mai University Library
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
description	Copyright © 2020 Elsevier Ltd. All rights reserved. The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from a hexane fractional extract and identified as agrostophillinol. This is the first report of agrostophillinol isolated from kaffir lime leaves. In terms of cytotoxicity, agrostophillinol exhibited IC50 values of 36.27 ± 7.30 and 53.44 ± 10.63 μg/mL against EoL-1 and HL60 cells, respectively. Agrostophillinol also exhibited potent anti-inflammatory activity, significantly inhibiting IL-6 secretion.
format	Journal
author	Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki
author_facet	Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki
author_sort	Songyot Anuchapreeda
title	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
title_short	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
title_full	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
title_fullStr	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
title_full_unstemmed	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
title_sort	isolation and biological activity of agrostophillinol from kaffir lime (citrus hystrix) leaves
publishDate	2020
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086355236&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70205
_version_	1681752860306440192

Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves

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