The roles of melatonin on kidney injury in obese and diabetic conditions

© 2020 International Union of Biochemistry and Molecular Biology Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increas...

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Main Authors: Sasivimon Promsan, Anusorn Lungkaphin
Format: Journal
Published: 2020
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/70207
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spelling th-cmuir.6653943832-702072020-10-14T08:25:36Z The roles of melatonin on kidney injury in obese and diabetic conditions Sasivimon Promsan Anusorn Lungkaphin Biochemistry, Genetics and Molecular Biology © 2020 International Union of Biochemistry and Molecular Biology Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell membranes of renal tissues leading to kidney injury. Obesity-mediated inflammation, oxidative stress, apoptosis, and mitochondrial dysfunction are the important causes and progression of CKD. Melatonin (N-acetyl-5-methoxytryptamine) is a neuronal hormone that is synthesized by the pineal gland and plays an essential role in regulating several physiological functions in the human body. Moreover, melatonin has pleiotropic effects such as antioxidant, anti-inflammation, antiapoptosis. In this review, the relationship between obesity, diabetic condition, and kidney injury and the renoprotective effect of melatonin in obese and diabetic conditions from in vitro and in vivo studies have been summarized and discussed. 2020-10-14T08:25:36Z 2020-10-14T08:25:36Z 2020-07-01 Journal 18728081 09516433 2-s2.0-85085548333 10.1002/biof.1637 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085548333&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70207
institution Chiang Mai University
building Chiang Mai University Library
continent Asia
country Thailand
Thailand
content_provider Chiang Mai University Library
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Sasivimon Promsan
Anusorn Lungkaphin
The roles of melatonin on kidney injury in obese and diabetic conditions
description © 2020 International Union of Biochemistry and Molecular Biology Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell membranes of renal tissues leading to kidney injury. Obesity-mediated inflammation, oxidative stress, apoptosis, and mitochondrial dysfunction are the important causes and progression of CKD. Melatonin (N-acetyl-5-methoxytryptamine) is a neuronal hormone that is synthesized by the pineal gland and plays an essential role in regulating several physiological functions in the human body. Moreover, melatonin has pleiotropic effects such as antioxidant, anti-inflammation, antiapoptosis. In this review, the relationship between obesity, diabetic condition, and kidney injury and the renoprotective effect of melatonin in obese and diabetic conditions from in vitro and in vivo studies have been summarized and discussed.
format Journal
author Sasivimon Promsan
Anusorn Lungkaphin
author_facet Sasivimon Promsan
Anusorn Lungkaphin
author_sort Sasivimon Promsan
title The roles of melatonin on kidney injury in obese and diabetic conditions
title_short The roles of melatonin on kidney injury in obese and diabetic conditions
title_full The roles of melatonin on kidney injury in obese and diabetic conditions
title_fullStr The roles of melatonin on kidney injury in obese and diabetic conditions
title_full_unstemmed The roles of melatonin on kidney injury in obese and diabetic conditions
title_sort roles of melatonin on kidney injury in obese and diabetic conditions
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085548333&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70207
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