The roles of melatonin on kidney injury in obese and diabetic conditions
© 2020 International Union of Biochemistry and Molecular Biology Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increas...
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th-cmuir.6653943832-702072020-10-14T08:25:36Z The roles of melatonin on kidney injury in obese and diabetic conditions Sasivimon Promsan Anusorn Lungkaphin Biochemistry, Genetics and Molecular Biology © 2020 International Union of Biochemistry and Molecular Biology Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell membranes of renal tissues leading to kidney injury. Obesity-mediated inflammation, oxidative stress, apoptosis, and mitochondrial dysfunction are the important causes and progression of CKD. Melatonin (N-acetyl-5-methoxytryptamine) is a neuronal hormone that is synthesized by the pineal gland and plays an essential role in regulating several physiological functions in the human body. Moreover, melatonin has pleiotropic effects such as antioxidant, anti-inflammation, antiapoptosis. In this review, the relationship between obesity, diabetic condition, and kidney injury and the renoprotective effect of melatonin in obese and diabetic conditions from in vitro and in vivo studies have been summarized and discussed. 2020-10-14T08:25:36Z 2020-10-14T08:25:36Z 2020-07-01 Journal 18728081 09516433 2-s2.0-85085548333 10.1002/biof.1637 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085548333&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70207 |
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Biochemistry, Genetics and Molecular Biology Sasivimon Promsan Anusorn Lungkaphin The roles of melatonin on kidney injury in obese and diabetic conditions |
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© 2020 International Union of Biochemistry and Molecular Biology Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell membranes of renal tissues leading to kidney injury. Obesity-mediated inflammation, oxidative stress, apoptosis, and mitochondrial dysfunction are the important causes and progression of CKD. Melatonin (N-acetyl-5-methoxytryptamine) is a neuronal hormone that is synthesized by the pineal gland and plays an essential role in regulating several physiological functions in the human body. Moreover, melatonin has pleiotropic effects such as antioxidant, anti-inflammation, antiapoptosis. In this review, the relationship between obesity, diabetic condition, and kidney injury and the renoprotective effect of melatonin in obese and diabetic conditions from in vitro and in vivo studies have been summarized and discussed. |
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Sasivimon Promsan Anusorn Lungkaphin |
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Sasivimon Promsan Anusorn Lungkaphin |
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Sasivimon Promsan |
title |
The roles of melatonin on kidney injury in obese and diabetic conditions |
title_short |
The roles of melatonin on kidney injury in obese and diabetic conditions |
title_full |
The roles of melatonin on kidney injury in obese and diabetic conditions |
title_fullStr |
The roles of melatonin on kidney injury in obese and diabetic conditions |
title_full_unstemmed |
The roles of melatonin on kidney injury in obese and diabetic conditions |
title_sort |
roles of melatonin on kidney injury in obese and diabetic conditions |
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2020 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085548333&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70207 |
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