Antioxidant and moisturizing properties of carboxymethyl chitosan with different molecular weights

• Main Authors: Nareekan Chaiwong, Pimporn Leelapornpisid, Kittisak Jantanasakulwong, Pornchai Rachtanapun, Phisit Seesuriyachan, Vinyoo Sakdatorn, Noppol Leksawasdi, Yuthana Phimolsiripol
• Format: Journal
• Published: 2020
• Subjects: Chemistry; Materials Science
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088284052&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/70382
• Institution: Chiang Mai University

© 2020 by the authors. This research aimed to synthesize carboxymethyl chitosan (CMCH) from different molecular weights of chitosan including low MW (L, 50-190 kDa), medium MW (M, 210-300 kDa) and high MW (H, 310-375 kDa) on the antioxidant and moisturizing properties. The L-CMCH, M-CMCH and H-CMCH improved the water solubility by about 96%, 90% and 89%, respectively when compared to native chitosan. Higher MW resulted in more viscous of CMCH. For antioxidant properties, IC50 values of DPPH and ABTS radical scavenging activity for L-CMCH were 1.70 and 1.37 mg/mL, respectively. The L-CMCH had higher antioxidant properties by DPPH and ABTS radical scavenging assay and FRAP. The moisturizing properties on pig skin using a Corneometer® showed that 0.5% H-CMCH significantly presented (p ≤ 0.05) greater moisturizing effect than that of untreated-skin, distilled water, propylene glycol and pure chitosan from three molecular weights.