Production of monoclonal antibodies to P-glycoprotein: Its application in detection of soluble and surface P-glycoprotein of leukemia patients

• Main Authors: Chiampanichayakul S., Anuchapreeda S., Chruewkamlow N., Mahasongkram K., Thanaratanakorn P., Kasinrerk W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77956896273&partnerID=40&md5=7a0918b59903cbbded5b676b0e358f15; http://www.ncbi.nlm.nih.gov/pubmed/20740331; http://cmuir.cmu.ac.th/handle/6653943832/739
• Institution: Chiang Mai University

Multidrug resistance (MDR) in leukemia is commonly associated with the expression of a transmembrane protein, P-glycoprotein (P-gp). In this study, two monoclonal antibodies (mAbs) specific for the extracellular domain of P-gp were generated. By employing the generated mAbs, a two-color lysed whole...