Anti-P-glycoprotein conjugated nanoparticles for targeting drug delivery in cancer treatment

• Main Authors: Iangcharoen P., Punfa W., Yodkeeree S., Kasinrerk W., Ampasavate C., Anuchapreeda S., Limtrakul P.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-82055176069&partnerID=40&md5=1b28ae43646f48c6f3dfb758518cf669; http://www.ncbi.nlm.nih.gov/pubmed/22076768; http://cmuir.cmu.ac.th/handle/6653943832/794
• Institution: Chiang Mai University

Targeting therapeutics to specific sites can enhance the efficacy of drugs, reduce required doses as well as unwanted side effects. In this work, using the advantages of the specific affinity of an immobilized antibody to membrane P-gp in two different nanoparticle formulations were thus developed f...