A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC...
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2014
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th-cmuir.6653943832-8472014-08-29T09:02:14Z A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity Pumsalid K. Thaisuchat H. Loetchutinat C. Nuntasaen N. Meepowpan P. Pompimon W. Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control. 2014-08-29T09:02:14Z 2014-08-29T09:02:14Z 2010 Article 1934578X 21299123 http://www.scopus.com/inward/record.url?eid=2-s2.0-78751539201&partnerID=40&md5=fc97eeb1243a923f5f194a419c41c012 http://cmuir.cmu.ac.th/handle/6653943832/847 English |
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English |
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Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control. |
| format |
Article |
| author |
Pumsalid K. Thaisuchat H. Loetchutinat C. Nuntasaen N. Meepowpan P. Pompimon W. |
| spellingShingle |
Pumsalid K. Thaisuchat H. Loetchutinat C. Nuntasaen N. Meepowpan P. Pompimon W. A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| author_facet |
Pumsalid K. Thaisuchat H. Loetchutinat C. Nuntasaen N. Meepowpan P. Pompimon W. |
| author_sort |
Pumsalid K. |
| title |
A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| title_short |
A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| title_full |
A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| title_fullStr |
A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| title_full_unstemmed |
A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| title_sort |
new azafluorenone from the roots of polyalthia cerasoides and its biological activity |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-78751539201&partnerID=40&md5=fc97eeb1243a923f5f194a419c41c012 http://cmuir.cmu.ac.th/handle/6653943832/847 |
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1681419560169766912 |