A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

• Main Authors: Pumsalid K., Thaisuchat H., Loetchutinat C., Nuntasaen N., Meepowpan P., Pompimon W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-78751539201&partnerID=40&md5=fc97eeb1243a923f5f194a419c41c012; http://cmuir.cmu.ac.th/handle/6653943832/847
• Institution: Chiang Mai University

Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC...