Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy

The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonic...

Full description

Saved in:
Bibliographic Details
Main Authors: Anuchapreeda S., Fukumori Y., Okonogi S., Ichikawa H.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84855688731&partnerID=40&md5=90d408d6e1b8c3f96149cb782e32899f
http://cmuir.cmu.ac.th/handle/6653943832/898
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
Description
Summary:The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenated L -α phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47-55nm, could incorporate 23-28mg curcumin per 30mL, and were stable in particle size for 60 days at 4°C. The cytotoxicity studies of curucumin solution and curcumin-loaded nanoemulsion using B16F10 and leukemic cell lines showed IC 50 values ranging from 3.5 to 30.1 and 22.2 to 53.7μM, respectively. These results demonstrated the successful incorporation of curcumin into lipid nanoemulsion particles with small particle size, high loading capacity, good physical stability, and preserved cytotoxicity. Copyright © 2012 Songyot Anuchapreeda et al.