Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy

The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonic...

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Main Authors: Anuchapreeda S., Fukumori Y., Okonogi S., Ichikawa H.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84855688731&partnerID=40&md5=90d408d6e1b8c3f96149cb782e32899f
http://cmuir.cmu.ac.th/handle/6653943832/898
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-8982014-08-29T09:02:18Z Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy Anuchapreeda S. Fukumori Y. Okonogi S. Ichikawa H. The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenated L -α phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47-55nm, could incorporate 23-28mg curcumin per 30mL, and were stable in particle size for 60 days at 4°C. The cytotoxicity studies of curucumin solution and curcumin-loaded nanoemulsion using B16F10 and leukemic cell lines showed IC 50 values ranging from 3.5 to 30.1 and 22.2 to 53.7μM, respectively. These results demonstrated the successful incorporation of curcumin into lipid nanoemulsion particles with small particle size, high loading capacity, good physical stability, and preserved cytotoxicity. Copyright © 2012 Songyot Anuchapreeda et al. 2014-08-29T09:02:18Z 2014-08-29T09:02:18Z 2012 Article 16879503 10.1155/2012/270383 http://www.scopus.com/inward/record.url?eid=2-s2.0-84855688731&partnerID=40&md5=90d408d6e1b8c3f96149cb782e32899f http://cmuir.cmu.ac.th/handle/6653943832/898 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenated L -α phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47-55nm, could incorporate 23-28mg curcumin per 30mL, and were stable in particle size for 60 days at 4°C. The cytotoxicity studies of curucumin solution and curcumin-loaded nanoemulsion using B16F10 and leukemic cell lines showed IC 50 values ranging from 3.5 to 30.1 and 22.2 to 53.7μM, respectively. These results demonstrated the successful incorporation of curcumin into lipid nanoemulsion particles with small particle size, high loading capacity, good physical stability, and preserved cytotoxicity. Copyright © 2012 Songyot Anuchapreeda et al.
format Article
author Anuchapreeda S.
Fukumori Y.
Okonogi S.
Ichikawa H.
spellingShingle Anuchapreeda S.
Fukumori Y.
Okonogi S.
Ichikawa H.
Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
author_facet Anuchapreeda S.
Fukumori Y.
Okonogi S.
Ichikawa H.
author_sort Anuchapreeda S.
title Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
title_short Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
title_full Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
title_fullStr Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
title_full_unstemmed Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
title_sort preparation of lipid nanoemulsions incorporating curcumin for cancer therapy
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84855688731&partnerID=40&md5=90d408d6e1b8c3f96149cb782e32899f
http://cmuir.cmu.ac.th/handle/6653943832/898
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