Innate and adaptive immune responses both contribute to pathological cd4 t cell activation in hiv-1 infected ugandans

• Main Authors: Michael A. Eller, Kim G. Blom, Veronica D. Gonzalez, Leigh Anne Eller, Prossy Naluyima, Oliver Laeyendecker, Thomas C. Quinn, Noah Kiwanuka, David Serwadda, Nelson K. Sewankambo, Boonrat Tasseneetrithep, Maria J. Wawer, Ronald H. Gray, Mary A. Marovich, Nelson L. Michael, Mark S. de Souza, Fred Wabwire-Mangen, Merlin L. Robb, Jeffrey R. Currier, Johan K. Sandberg
• Other Authors: Makerere University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11321
• Institution: Mahidol University

HIV-1 disease progression is associated with persistent immune activation. However, the nature of this association is incompletely understood. Here, we investigated immune activation in the CD4 T cell compartment of chronically HIV-1 infected individuals from Rakai, Uganda. Levels of CD4 T cell acti...