Expansion of Stem Cell-Like CD4⁺ Memory T Cells during Acute HIV-1 Infection Is Linked to Rapid Disease Progression

• Main Authors: Jernej Pušnik, Michael A. Eller, Boonrat Tassaneetrithep, Bruce T. Schultz, Leigh Anne Eller, Sorachai Nitayaphan, Josphat Kosgei, Lucas Maganga, Hannah Kibuuka, Galit Alter, Nelson L. Michael, Merlin L. Robb, Hendrik Streeck
• Other Authors: Makerere University
• Format: Article
• Published: 2020
• Subjects: Agricultural and Biological Sciences; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/49751
• Institution: Mahidol University

Copyright © 2019 American Society for Microbiology. Acute HIV-1 infection is characterized by high viremia and massive depletion of CD4+ T cells throughout all tissue compartments. During this time the latent viral reservoir is established but the dynamics of memory CD4+ T cell subset development, t...