FLT3 and NPM1 gene mutations in childhood acute myeloblastic leukemia

• Main Authors: Ekchol Mukda, Katsarin Pintaraks, Rachchadol Sawangpanich, Surapon Wiangnon, Samart Pakakasama
• Other Authors: Thammasat University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11640
• Institution: Mahidol University

Mutations of receptor tyrosine kinases are implicated in the constitutive activation and development of human hematologic malignancies. Mutations in fms-like tyrosine kinase 3 (FLT3) gene including internal tandem duplication (ITD) and point mutation in the tyrosine kinase domain (TKD) as well as in...