Synthesis and structure-activity relationship of 2-thiopyrimidine-4-one analogs as antimicrobial and anticancer agents

Considering that some thiopyrimidines were previously reported as potential therapeutics, the present study achieved novel analogs of bioactive 2-substituted thiopyrimidines-4-(3H)-ones via base catalyzed alkylation reaction of 2-thiouracil using alkyl and aralkyl bromides. The title compounds were...

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Main Authors: Supaluk Prachayasittikul, Apilak Worachartcheewan, Chanin Nantasenamat, Maneekarn Chinworrungsee, Nirun Sornsongkhram, Somsak Ruchirawat, Virapong Prachayasittikul
Other Authors: Srinakharinwirot University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/11731
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Institution: Mahidol University

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