Involvement of P2X<inf>7</inf>purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts

• Main Authors: P. Montreekachon, P. Chotjumlong, J. G.M. Bolscher, K. Nazmi, V. Reutrakul, S. Krisanaprakornkit
• Other Authors: Chiang Mai University
• Format: Article
• Published: 2018
• Subjects: Dentistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11830
• Institution: Mahidol University

Background and Objective: The antimicrobial peptide LL-37, derived from human neutrophils, can directly chemoattract leukocytes and up-regulate the expression of several immune-related genes in various cell types. In this study, we wanted to determine the immunoregulatory effect of LL-37 on interleu...