Decreased expression of surfactant protein D mRNA in human lungs in fatal cases of H5N1 avian influenza

• Main Authors: Alita Kongchanagul, Ornpreya Suptawiwat, Chompunuch Boonarkart, Rungrueng Kitphati, Pilaipan Puthavathana, Mongkol Uiprasertkul, Prasert Auewarakul
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12018

Microarray analysis of gene expression profile of lungs from two fatal H5N1 influenza cases identified 3,435 genes with higher than twofold changes in mRNA levels as compared to those of normal lung. One thousand nineteen genes and 2,416 genes were up-regulated and down-regulated commonly, respectiv...