N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

Dengue virus (DENV) NS1 is a versatile non-structural glycoprotein that is secreted as a hexamer, binds to the cell surface of infected and uninfected cells, and has immune evasive functions. DENV NS1 displays two conserved N-linked glycans at N130 and N207. In this study, we examined the role of th...

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Bibliographic Details
Main Authors: Pawit Somnuke, Richard E. Hauhart, John P. Atkinson, Michael S. Diamond, Panisadee Avirutnan
Other Authors: Washington University in St. Louis, School of Medicine
Format: Article
Published: 2018
Subjects:
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/12048
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/12048

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