N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

• Main Authors: Pawit Somnuke, Richard E. Hauhart, John P. Atkinson, Michael S. Diamond, Panisadee Avirutnan
• Other Authors: Washington University in St. Louis, School of Medicine
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12048
• Institution: Mahidol University

Dengue virus (DENV) NS1 is a versatile non-structural glycoprotein that is secreted as a hexamer, binds to the cell surface of infected and uninfected cells, and has immune evasive functions. DENV NS1 displays two conserved N-linked glycans at N130 and N207. In this study, we examined the role of th...