Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children

• Main Authors: Kulkanya Chokephaibulkit, Tim R. Cressey, Edmund Capparelli, Virat Sirisanthana, Petronella Muresan, Suchat Hongsiriwon, Chaiwat Ngampiyaskul, Chanin Limwongse, Orasri Wittawatmongkol, Linda Aurpibul, Bill Kabat, Mari Pat Toye, Mary Elizabeth Smith, Achara Eksaengsri, Kenneth McIntosh, Ram Yogev
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12151

Background: Alternatives to the available stavudine-containing paediatric fixed-dose combination (FDC) tablets are rapidly needed due to concerns regarding the cumulative toxicity of long-term stavudine exposure. We report the bioavailability and short-term safety of a novel paediatric FDC tablet of...