The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum

The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum

Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC 50 ) of P. vivax and P. falciparum to artesunate and chloroquine rela...

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Bibliographic Details
Main Authors: S. Kaewpongsri, K. Sriprawat, R. Suwanarusk, D. E. Kyle, U. Lek-Uthai, M. Leimanis, K. M. Lwin, A. P. Phyo, J. Zwang, B. Russell, F. Nosten, L. Renia
Other Authors: Shoklo Malaria Research Unit
Format: Article
Published: 2018
Subjects:
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/12627
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Institution: Mahidol University
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Summary:Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC 50 ) of P. vivax and P. falciparum to artesunate and chloroquine relative to results with the paired leukocyte-free treatment. Although leukocyte removal is not an essential requirement for the conduct of ex vivo assays, its use has important implications for the interpretation of temporal and spatial antimalarial sensitivity data. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

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