The inhibitory effect of capsaicin on intestinal glucose absorption in vitro. II. Effect of capsaicin upon intestinal Na<sup>+</sup>-K<sup>+</sup>-ATPase activities
14.0 mg/100 ml capsaicin, incubated in everted sac preparations, produced no significant inhibition of intestinal Na + -K + -ATPase in the rat, but a 22.60% inhibition in the hamster. This differential effect was substantiated by in vitro studies of aliquots of crude mucosal homogenate. the ID 50 s...
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| Format: | Article |
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2018
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| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/13283 |
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| Institution: | Mahidol University |
| Summary: | 14.0 mg/100 ml capsaicin, incubated in everted sac preparations, produced no significant inhibition of intestinal Na + -K + -ATPase in the rat, but a 22.60% inhibition in the hamster. This differential effect was substantiated by in vitro studies of aliquots of crude mucosal homogenate. the ID 50 s for rat and hamster being 35.0 and 12.0 mg/100 ml, respectively. Capsaicin-induced-inhibition of intestinal glucose transport may be due in part to a secondary inhibitory effect on the ATPase dependent sodium pump. © 1979. |
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