A new conjugated amide-dimer from the aerial parts of Piper submultinerve

A new conjugated amide-dimer from the aerial parts of Piper submultinerve

Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pelli...

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Bibliographic Details
Main Authors: Saksit Nobsathian, Patoomratana Tuchinda, Darunee Soorukram, Manat Pohmakotr, Vichai Reutrakul, Chalobon Yoosook, Jitra Kasisit, Chanita Napaswad
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/13388
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Institution: Mahidol University
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Summary:Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and aristolactam BII (8) showed significant activities in the anti-syncytium assay using ΔTat/Rev MC99 virus and 1A2 cell line system, whereas 2 was most active (EC 50 35.1μM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC 50 50.8μM. © 2012 Copyright Taylor and Francis Group, LLC.

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