A new conjugated amide-dimer from the aerial parts of Piper submultinerve

Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pelli...

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Main Authors: Saksit Nobsathian, Patoomratana Tuchinda, Darunee Soorukram, Manat Pohmakotr, Vichai Reutrakul, Chalobon Yoosook, Jitra Kasisit, Chanita Napaswad
Other Authors: Mahidol University
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/13388
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spelling th-mahidol.133882018-06-11T11:42:29Z A new conjugated amide-dimer from the aerial parts of Piper submultinerve Saksit Nobsathian Patoomratana Tuchinda Darunee Soorukram Manat Pohmakotr Vichai Reutrakul Chalobon Yoosook Jitra Kasisit Chanita Napaswad Mahidol University Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Chemistry Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and aristolactam BII (8) showed significant activities in the anti-syncytium assay using ΔTat/Rev MC99 virus and 1A2 cell line system, whereas 2 was most active (EC 50 35.1μM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC 50 50.8μM. © 2012 Copyright Taylor and Francis Group, LLC. 2018-06-11T04:29:31Z 2018-06-11T04:29:31Z 2012-10-01 Article Natural Product Research. Vol.26, No.19 (2012), 1824-1830 10.1080/14786419.2011.639071 14786427 14786419 2-s2.0-84866531554 https://repository.li.mahidol.ac.th/handle/123456789/13388 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866531554&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Chemistry
spellingShingle Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Chemistry
Saksit Nobsathian
Patoomratana Tuchinda
Darunee Soorukram
Manat Pohmakotr
Vichai Reutrakul
Chalobon Yoosook
Jitra Kasisit
Chanita Napaswad
A new conjugated amide-dimer from the aerial parts of Piper submultinerve
description Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and aristolactam BII (8) showed significant activities in the anti-syncytium assay using ΔTat/Rev MC99 virus and 1A2 cell line system, whereas 2 was most active (EC 50 35.1μM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC 50 50.8μM. © 2012 Copyright Taylor and Francis Group, LLC.
author2 Mahidol University
author_facet Mahidol University
Saksit Nobsathian
Patoomratana Tuchinda
Darunee Soorukram
Manat Pohmakotr
Vichai Reutrakul
Chalobon Yoosook
Jitra Kasisit
Chanita Napaswad
format Article
author Saksit Nobsathian
Patoomratana Tuchinda
Darunee Soorukram
Manat Pohmakotr
Vichai Reutrakul
Chalobon Yoosook
Jitra Kasisit
Chanita Napaswad
author_sort Saksit Nobsathian
title A new conjugated amide-dimer from the aerial parts of Piper submultinerve
title_short A new conjugated amide-dimer from the aerial parts of Piper submultinerve
title_full A new conjugated amide-dimer from the aerial parts of Piper submultinerve
title_fullStr A new conjugated amide-dimer from the aerial parts of Piper submultinerve
title_full_unstemmed A new conjugated amide-dimer from the aerial parts of Piper submultinerve
title_sort new conjugated amide-dimer from the aerial parts of piper submultinerve
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/13388
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