BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7

• Main Authors: Olivier Goupille, Tipparat Penglong, Carine Lefèvre, Marine Granger, Zahra Kadri, Suthat Fucharoen, Leila Maouche-Chrétien, Philippe Leboulch, Stany Chrétien
• Other Authors: CEA Fontenay aux Roses
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13548
• Institution: Mahidol University

Malignant transformation is a multistep process requiring oncogenic activation, promoting cellular proliferation, frequently coupled to inhibition of terminal differentiation. Consequently, forcing the reengagement of terminal differentiation of transformed cells coupled or not with an inhibition of...