X-chromosome inactivation in monkey embryos and pluripotent stem cells

• Main Authors: Masahito Tachibana, Hong Ma, Michelle L. Sparman, Hyo Sang Lee, Cathy M. Ramsey, Joy S. Woodward, Hathaitip Sritanaudomchai, Keith R. Masterson, Erin E. Wolff, Yibing Jia, Shoukhrat M. Mitalipov
• Other Authors: Oregon National Primate Research Center
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13574
• Institution: Mahidol University

Inactivation of one X chromosome in female mammals (XX) compensates for the reduced dosage of X-linked gene expression in males (XY). However, the inner cell mass (ICM) of mouse preimplantation blastocysts and their in vitro counterparts, pluripotent embryonic stem cells (ESCs), initially maintain t...