Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection

• Main Authors: Chayanee Setthapramote, Tadahiro Sasaki, Orapim Puiprom, Kriengsak Limkittikul, Pannamthip Pitaksajjakul, Chonlatip Pipattanaboon, Mikiko Sasayama, Pornsawan Leuangwutiwong, Weerapong Phumratanaprapin, Supat Chamnachanan, Teera Kusolsuk, Akanitt Jittmittraphap, Azusa Asai, Juan Fernando Arias, Itaru Hirai, Motoki Kuhara, Yoshinobu Okuno, Takeshi Kurosu, Pongrama Ramasoota, Kazuyoshi Ikuta
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13665

The global spread of the four dengue virus serotypes (DENV-1 to -4) has made this virus a major and growing public health concern. Generally, pre-existing neutralizing antibodies derived from primary infection play a significant role in protecting against subsequent infection with the same serotype....