Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria

• Main Authors: Thiranut Ramutton, Ilse Ce Hendriksen, Juliet Mwanga-Amumpaire, George Mtove, Rasaq Olaosebikan, Antoinette K. Tshefu, Marie A. Onyamboko, Corine Karema, Kathryn Maitland, Ermelinda Gomes, Samwel Gesase, Hugh Reyburn, Kamolrat Silamut, Kesinee Chotivanich, Kamoltip Promnares, Caterina I. Fanello, Lorenz Von Seidlein, Nicholas Pj Day, Nicholas J. White, Arjen M. Dondorp, Mallika Imwong, Charles J. Woodrow
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14286

Background: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These iss...