Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement

• Main Authors: Ilse C.E. Hendriksen, Juliet Mwanga-Amumpaire, Lorenz von Seidlein, George Mtove, Lisa J. White, Rasaq Olaosebikan, Sue J. Lee, Antoinette K. Tshefu, Charles Woodrow, Ben Amos, Corine Karema, Somporn Saiwaew, Kathryn Maitland, Ermelinda Gomes, Wirichada Pan-Ngum, Samwel Gesase, Kamolrat Silamut, Hugh Reyburn, Sarah Joseph, Kesinee Chotivanich, Caterina I. Fanello, Nicholas P.J. Day, Nicholas J. White, Arjen M. Dondorp
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14722

Background: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered parasites and can be used to esti...