Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions

• Main Authors: Jeehyea Choi, Patarabutr Masaratana, Gladys O. Latunde-Dada, Matthew Arno, Robert J. Simpson, Andrew T. McKie
• Other Authors: King's College London
• Format: Article
• Published: 2018
• Subjects: Medicine; Nursing
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14571
• Institution: Mahidol University

Duodenal cytochrome b (Dcytb, Cybrd1) is a ferric reductase localized in the duodenum that is highly upregulated in circumstances of increased iron absorption. To address the contribution of Dcytb to total duodenal ferric reductase activity as well as its wider role in iron metabolism, we first meas...