Calpastatin reduces calpain and caspase activation in methamphetamine-induced toxicity in human neuroblastoma SH-SY5Y cultured cells

• Main Authors: Wilasinee Suwanjang, Pansiri Phansuwan-Pujito, Piyarat Govitrapong, Banthit Chetsawang
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15126

Methamphetamine (METH) is an abused psychostimulant drug that can cause neurotoxicity to dopaminergic cells. It has been demonstrated that METH can induce caspase- and calpain-dependent death cascades. The purpose of the present study was to investigate the functional role of calpastatin, a specific...